郭妍，女，1992年生，山西五台人，中共党员，博士，硕士生导师。2021年12月毕业于华南农业大学，同年进入w88win优德任教。研究方向：功能食品开发、分子模拟。联系邮箱：guoyan@sxnu.edu.cn

一、发表论文：

1. Yan Guo, Jinchang Tong, Yilin Guo, Xinyue Song, Kaixin Shi, Zichao Guo, Boping Liu*, Jianguo Xu*, Interaction, stability and bioaccessibility of bovine serum albumin-quercetin/myricetin complexes: Multi-spectroscopy and molecular dynamics simulation studies, Food Hydrocolloids, 2025, 110836.

2. Yan Guo, Jianhuai Liang, Boping Liu*, Yulong Jin*, Molecular Mechanism of Food-Derived Polyphenols on PD-L1 Dimerization: A Molecular Dynamics Simulation Study, International Journal of Molecular Sciences, 2021, 20.

3. Yan Guo, Yulong Jin*, Bingfeng Wang, Boping Liu*, Molecular Mechanism of Small-Molecule Inhibitors in Blocking the PD-1/PD-L1 Pathway through PD-L1 Dimerization, International Journal of Molecular Sciences, 2021, 9.

4. Yan Guo, Jinchang Tong, Jianhuai Liang, Kaixin Shi, Xinyue Song, Zichao Guo, Boping Liu*, Jianguo Xu*, Molecular insight into binding affinities and blockade effects of selected flavonoid compounds on the PD-1/PD-L1 pathway, RSC Advances, 2024, 14.

5.Yan Guo, Liping Sun, Yongliang Zhuang, UPLC-Q-Orbitrap-MS2 analysis of Moringa oleifera leaf extract and its antioxidant, antibacterial and anti-inflammatory activities, Natural Product Research, 2020, 34.

6. 郭妍, 郭怡琳, 刘柏平*, 徐建国*, 基于分子动力学模拟与实验验证探讨黄芩素抑制PD-1/PD-L1相互作用的分子机制, 食品工业科技, 2024, 02.

二、科研项目：

1. 山西省自然科学基金，黄芩素/黄芩苷抑制PD-1/PD-L1相互作用的分子动力学模拟和体外活性研究，2023.01-2025.12, 在研，主持。

2. w88win优德自然科学基金，多酚抑制PD-1/PD-L1通路的分子机制研究，w88win优德自然科学基金，2024.11-2026.11，在研，主持。